Ionomycin,Free Acid,from Streptomyces conglbatus
Ionomycin (free acid)
CAS: 56092-81-0
Molecular Formula: C41H72O9
Ionomycin,Free Acid,from Streptomyces conglbatus - Names and Identifiers
| Name | Ionomycin (free acid) |
| Synonyms | SQ-23377 IONOMYCIN Ionomycin SQ 23377, EM 94 Ionomycin (free acid) Ionomycin,Free Acid,from Streptomyces conglbatus Ionomycin, free acid, from Streptomyces conglobatus Ionomycin,Free Acid,from Streptomyces conglbatus ionomycin calcium salt from streptomyces conglobatus (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid (4R,6S,8S,10Z,12R,14R,16E,18S,19S,20R,21S)-11,19,21-Trihydroxy-22-{(2S,2'S,5S,5'R)-5'-[(1S)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid (4R,6S,8R,12R,14S,18S,19R,20R,21R)-19,21-Dihydroxy-22-[(2R,5R)-5-[(2R,5S)-5-(1-hydroxyethyl)-5-methyl-oxolan-2-yl]-5-methyl-oxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-docosa-10,16-dienoate calcium salt |
| CAS | 56092-81-0 |
Ionomycin,Free Acid,from Streptomyces conglbatus - Physico-chemical Properties
| Molecular Formula | C41H72O9 |
| Molar Mass | 709.01 |
| Density | 1.072±0.06 g/cm3(Predicted) |
| Melting Point | 204℃-206℃ |
| Boling Point | 817.2±65.0 °C(Predicted) |
| Solubility | Soluble to 10 mM in Ethanol and to 10 mM in DMSO |
| Appearance | Morphological Waxy solid |
| Color | Yellow |
| BRN | 3642126 |
| pKa | 4.77±0.10(Predicted) |
| Storage Condition | −20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Sensitive | Sensitive to light |
| MDL | MFCD06798385 |
| Physical and Chemical Properties | Bioactive Ionomycin (SQ23377) is an effective and selective calcium ionophore (calcium ionophore) and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr = Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin (SQ23377) also induces protein kinase C (PKC) activation. |
| Use | Ionomycin is more effective than A23187 as a Ca ionophore. Ionomycin is used in research on Ca transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons |
| In vitro study | Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus . Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca 2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment. Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment. |
Ionomycin,Free Acid,from Streptomyces conglbatus - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | NO0650000 |
| FLUKA BRAND F CODES | 8-10 |
| HS Code | 29419090 |
| Hazard Class | 3 |
Ionomycin,Free Acid,from Streptomyces conglbatus - Reference
| Reference Show more | 1. Luo Yuan Tang Lan Liao Chunshu. The level and significance of Th9/Th17 in peripheral blood of patients with primary immune thrombocytopenia [J]. Journal of Central South Medical Sciences 2019 047(003):294-298. 2. Su Yang, Ren Wenchen, Li Shanshan, et al. Effect of yangjinhua on intestinal Th17/Treg axis in mice with psoriasis based on intestinal-immune-skin axis [J]. Modern Chinese medicine research and practice, 2018, 32(05):31-34. |
Supplier List
Product Name: Ionomycin (free acid) Visit Supplier Webpage Request for quotation
CAS: 56092-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 56092-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Ionomycin (free acid) Visit Supplier Webpage Request for quotation
CAS: 56092-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 56092-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History